Abstract: Objective: To investigate the factors influencing residual cervical lymph node metastasis in NPC patients after radiotherapy and to suggest a regimen for minimizing residual lymphatic metastasis in the cervical region. Methods: Data from 260 NPC patients with cervical lymph node metastasis, of which 100 had a residual mass in the neck after radiotherapy, were collected and studied using SPSS 13.0 software. The evaluated factors included 24 parameters such as gender, age, family history, accompanying disease, lymph node position, lymph node number, lymph node size, lymph node rigidity, lymph node activity, pathology, T stage, N stage, etc. Univariate analysis was performed using a Chi-Square test and multivariate analysis was performed using logistic regression modeling. Results: Univariate analysis revealed a significant relationship between 16 factors: lymph node position, number, size, activity, T stage, N stage, chemotherapy, dose in NP, dose in lymph node, hyperthermia, WBC, HGB, upper gastrointestinal reaction, neck skin reaction, and buccal mucosa. Univariate analysis showed that 8 factors were independent prognostic factors: lymph node position, size, activity, T stage, chemotherapy, dose in lymph node, upper gastrointestinal reaction, and neck skin reaction. Conclusions: Comprehensive consideration of the lymph node position, size, activity, T stage,chemotherapy, dose in lymph node, upper GI reaction, and neck skin reaction during the planning of radiotherapy can be of help for minimizing residual cervical lymph node metastasis.