Abstract: Objective: To explore the clinical value of interventional treatment for inoperable malignant gastroduodenal obstruction. Methods: Data of 45 patients with symptoms of obstruction were reviewed, including 17 with pyloric antrum obstruction, 22 with duodenal obstruction, and 6 with stenotic gastroenterostomy. Under fluoroscopic guidance, 47 metallic self-expanding stents were implanted orally. TAI (transcatheter arterial infusion) was performed for 13 patients after 1 to 2 weeks. Results: Implantation was successfully conducted for 44 patients, with a success rate of 97.8%. Immediate relief of the obstruction was observed and all patients were able to take soft food. No severe complications occurred. The follow-up period was 2 to 15 months, and the mean survival time was 5.5 months. Conclusion: The implantation of metallic self-expanding stents is a simple, effective and safe method for treatment of patients with inoperable malignant gastroduodenal obstruction.