Abstract: To determine the effects of neoadjuvant chemotherapy on locally advanced cervical cancer. Methods: Forty patients with locally advanced stage Ⅰb and Ⅱb cervical cancer were chosen for the experimental group. They received 1 to 2 courses of treatment consisting of cisplatin, mitomycin and fluorouracil. After the chemotherapy regimen was completed, the patients underwent radical surgery. A group of 31 cases with the same diagnoses received radical surgery alone. This group was considered the control group. The patients were followed for 3 years. The rate of lymph node metastasis, the rate of recurrence and the survival time were compared between the two groups. Results:The effective rate of chemotherapy for patients in the experimental group was 70.00%. In that group, the rate of pelvic lymph node metastasis and relapse rate were significantly lower compared to the control group (P<0.05, P<0.05). The tumor- free time and the postoperative survival time in patients of the experimental group were also significantly longer compared to the controls (P=0.0136, P=0.0108).The lymph node metastasis rate and relapse rate were significantly lower for patients in the experimental group who responded well to the chemotherapy compared to those patients in the experimental group who did not respond well to the treatment (P<0.05, P<0.05). The tumor- free time and the postoperative survival time of the patients in the experimental group who responded well to the treatment were also significantly longer than those with a poor response (P=0.0116, P=0.0172). Conclusion: Neoadjuvant chemotherapy is beneficial for diminishing gross tumor volume, reducing the rate of lymph node metastasis and relapse, and prolonging the survival time of patients with locally advanced cervical cancer.The PMF regimen is effective in the treatment of locally advanced cervical cancer.