Abstract:
Objective: To explore the relationship between the age of onset for cervical carcinoma of two different histopathologic types, to offer clinical evidence for prognosis and to suggest a reasonable age to begin screening for cervical carcinoma. Methods: A retrospective analysis was performed using data from 573 patients with early stage cervical carcinoma (Stage Ia-IIa) undergoing surgical treatment between January 2000 and December 2004. Cervical biopsy was used to make a definitive diagnosis for all cases. The FIGO standards (1994) were used for determining clinical stage. All subjects were subdivided into 6 groups based on age brackets, ≤25, 26 to 35, 36 to 45, 46 to 55, 56 to 65 and ≥66 years old. Composition and distribution of the cervical carcinomas of different pathologic types were observed. Results: Of the 573 cervical carcinoma cases, 492 were confirmed as squamous cell carcinoma and 81 were adenocarcinoma. The mean age of the patients with squamous cell carcinoma of the cervix was 42.4 years, with a median age of 43. The ratio of patients with squamous cell carcinoma in each age group was 2.2%, 21.7%, 42.5%, 24.2%, 7.9% and 1.4% respectively. The mean age of patients with adenocarcinoma of the uterine cervix (AUC) was 41.9 years, with a median age of 41. The percentage of patients with AUC in each age group was 4.7%, 18.8%, 30.6%, 34.1%, 11.8% and 0%. For both types of cervical carcinoma, the proportion of young patients (<35years) with cervical carcinoma accounted for 24.1%. Conclusion: There is no significant difference in the age of onset between patients with squamous cell carcinoma of the cervix and patients with cervical adenocarcinoma (P> 0.05). Patients with cervical carcinoma tend to be young (<35 years) at the age of onset.