Abstract: Objective: To explore the effect of ALDH2 genotypes on liver function after percutaneous absolute alcohol injection(PAAI). Methods: Serum ALT, aspartate aminotransferase (AST) and γ -glutamyltransferase (GGT) were examined before and after percutaneous absolute alcohol injection (PAAI), and aldehyde dehydrogenase- 2 genome was detected using polymerase chain reaction- restriction fragment length polymorphism(PCR- RFLP) method. Results: All parameter of the liver function, after the PAAI, were increased and the results of ALT and AST in the ALDH2*1 genotype patients after PAAI were 25.64± 13.24 and 28.36 ± 19.21, respectively. In comparison with those in the ALDH2*2 genotype patients (63.33± 27.81 and 76.11± 31.39), there was a significant difference between the two (P=0.022 and P=0.017). Conclusion: The findings indicated that liver damage might increase largely in the ALDH2*1 genotypes patients after PAAI.