Abstract: Objective: Extranodular NK/T cell Lymphoma (nasal- type lymphoma) is a chemoresistant subtype of malignant lymphoma. In clinical practice, it is still very difficult to treat patients with advanced nasal- type lymphoma. Our study investigates the expression status of CD117 and PDGFRa in nasal- type lymphoma to analyze the correlation between expression of these proteins and clinical char-acteristics and to discuss clinical diagnosis based on the clinicopathological data. Methods: A complete set of detailed clinical, pathological and follow- up data for 37 cases with nasal- type lymphoma were included in our study. The expression of CD117 and PDGFRa was detected using a 2- step immunohisto-chemical staining method, and the results were appraised based on the ratio between the staining magnitude and the number of stained cells. The correlation analysis was conducted using the four- fold table precise probability ratio determination (log- rank method) and survival analysis was determined using a Kaplan- Meier curve. Results: The overexpression rates of CD117 and PDGFRa in 37 patients were 41% and 78%, respectively. The expression of CD117 and PDGFRa was not correlated with the clinical characteristics and did not show any prognostic significance. Conclusion: CD117 and PDGFRa are overexpressed in some cases of nasal- type lymphoma. Nasal- type lymphoma is a potential indicator of chemoresistance to STI571 and is worthy of further investigation.