Abstract: Objective: To confirm the expression and distribution of aquaporin 1(AQP1), 2 (AQP2)and 3 (AQP3) in prostate carcinoma and to probe into its significance in the progression of prostate carcinoma. Methods: The prostate cancer tissues of 20 cases and normal prostate tissues of 15 cases were obtained and the expression and distribution of AQP 1, AQP 2 and AQP 3 in carcinoma and normal prostate tissues were examined using immunohistochemistry. Results: The majority of AQP1 expression was found in the vascular endothelial cells, tumor cells and glandular organs. Sporadic expression of AQP2 could be detected in both normal prostate tissues and in the prostate cancer samples.AQP3 expression was found mainly in the pseudostratified columnar epithelium signifying possible involvement in secretion. Conclusion: AQP1 is mainly expressed in prostate carcinoma tissue where it is distributed in vascular endothelial cells, increasing permeable transport of water through the tumor's epithelium and blood vessels, thus promoting the development and metastasis of prostate carcinoma tumors.