Abstract: Objective: To study the expression of the products of the HBV genome and HSP70 in hepatitis- related hepatocellular carcinomas and to determine the possible mechanism in the course of carcinogenesis. Methods: Samples from a total of 152 cases with carcinoma and 78 cases with post-hepatitis liver cirrhosis were stained immunohistochemically in tissue array format to detect expression of the HBV antigens HBsAg, HBcAg, HBxAg and HSP70. Results: The expression levels of HBcAg,HBxAg, and HSP70 were significantly higher in carcinoma than in cirrhosis (P=0.000, P=0.005 and P=0.000, respectively). The expression of HBsAg was significantly lower in carcinoma than in cirrhosis (P=0.000). Correlation analysis showed that the expression of HSP70 was significantly correlated with the expression of HBcAg (P=0.009) but was not related to the HBxAg (P=0.673). Conclusion: HBcAg,HBxAg and HSP70 participate in the development of hepatitis - related hepatocellular carcinoma;HBcAg may take part in such a course by a mechanism related to HSP70. HBcAg may be involved in carcinogenesis through an increase in HSP70 expression.