Abstract: Objective: To evaluate the clinical value of CT- guided percutaneous fine needle aspiration for the pulmonary nodules less than or equivalent to 2.0 cm in diameter around great vessels.Method: Seventy- two patients underwent CT- guided percutaneous fine needle aspiration. Sensitivity,specificity and accuracy were calculated, and complications were analyzed. Results: Diagnostic sensitivity and positive prediction value of malignant diseases was 83.3% and 100%, and diagnostic specificity and negative prediction value of the benign diseases was 100% and 66.7%, respectively. The accuracy was 84.7%. Pneumothorax and bleeding occurred in 6.9% (5/72) and 8.3% (6/72) of the cases,respectively. Emphysema around the lesion was a significant complication after the aspiration. However,the position, size and depth of the pulmonary nodules have no correlation with the occurrence of complications. Conclusion: CT- guided percutaneous fine needle aspiration in small pulmonary nodules near the great vessels has a high diagnostic accuracy and a low complication incidence.