Abstract: Objective: To establish effective therapy for epiglottic cancer involving the root of the tongue. Methods: All 21 patients with epiglottic carcinoma involving the root of the tongue received radical neck dissection, horizontal partial laryngectomy and lingual- root plasty of the sternohyoid myofascial flap and then postoperative radiotherapy was performed. Results: No postoperative necrosis of the lingual root was found and all patients resumed normal pronunciation, deglutition and tongue extension functions. Follow- up was carried out for 3 to 5 years, and loss of visit occurred in only 3 cases. A 3- year survival was found in 15 of the 21 cases (71.4%), 4- year survival was found in 10 of the 18 cases (55.6%) and 5- year survival was found in 6 of the 14 cases (42.9%). The decannulation rate was 100%. Conclusion: Neck dissection, horizontal partial laryngectomy and sternohyoid myofascial flap plasty with postoperative radiotherapy was a reasonable and safe method for treatment of epiglottic carcinoma involving the root of tongue.