Abstract: Objective: To study 96 young patients with colon cancer seen in our cancer center to determine prognostic factors by univariate and multivariate analysis. Methods: A total of 723 patients with colon cancer were treated surgically during a period of 10 years. Ninety-six of them were younger than 40 years old. R0, R1 and R2 operations were carried out in 69 patients (71.9% of the group younger than 40), 4 patients (4.1%) and 23 patients (24%), respectively. Forty-three patients underwent left hemicolectomy, 37 patients had hemicolectomy on the right side, 9 patients underwent transverse colon resection and 7 patients had low anterior resection. Results: Intrasurgical mortality was 0%, but54 patients were dead within 111 months postoperatively due to recurrence or metastases of the tumor.Liver, lung and bone metastases occurred in 3, 1 and 5 patients, respectively. The median survival time for all patients was 77.9± 5.01 months and the overall 3-, 5-and 10-year survival rates were 66.68%,58.14% and 46.54%, respectively. In the univariate survival analysis, patient age, type of surgery performed, extent of resection, blood transfusion, histological type, diameter of the tumors, depth of tumor invasion, lymphatic invasion, distant metastases, liver metastases and TNM stage are predictors of survival in young patients with colon cancer. In the Cox-Regression analysis, blood transfusion and lymphatic invasion were determined to be independent prognostic factors for survival. Conclusions:Based on univariate analysis we found that patient age, type of surgery performed, extent of resection,blood transfusion, histological type, diameter of the tumors, depth of tumor invasion, lymphatic invasion,distant metastases and TNM stage were predictors of survival. Blood transfusion and lymphatic invasionwere the only statistically significant prognostic factors by multivariate analysis.