Abstract: Objective :To analyze the clinical characteristics and treatment response of 163 caseswith peripheral T-cell lymphoma unspecified (PTCL-U) and to explore the association between its clin-ical characteristics and prognosis. Methods :163 cases with PTCL-U treated between January 2002and December 2006 in Guangxi Cancer Hospital were retrospectively analyzed.The association betweenclinical features and the probability of attaining complete remission (CR) was evaluated by Chi-squaretest. Results :The median age of patients was 39 years, and the male-to-female ratio was 2.4:1.Theextranodal involvement rate was 74.85% and Waldeyer's ring was the most frequent site.The CR ratewas 43.56% and the factors associated with a lower probability of achieving CR were advanced disease(stage III-IV),the presence of extranodal involvement, poor performance status (PS), high LDH levels,bulky disease and International Prognostic Index (IPI). Conclusion :There is a preponderance of malesand a low CR rate in cases with PTCL-U. IPI is shown to be of highly significant prognostic value.