Abstract: Objective: To summarize the experience in diagnosis and surgical treatment of 105 cases with tumors of the chest wall, and to investigate reconstruction of a large chest wall defect after resection of chest wall tumors. Methods: Clinical data of 105 patients with tumors of the chest wall were retrospectively analyzed, among them 78 were males and 27 were females. Their ages ranged from 6 to 70 years. Of the 105 cases, 94 were primary tumors among which 75 were benign tumor cases, 19were malignant and the remaining 11 were metastatic. Reconstruction of a large chest wall defect was conducted after a resection of the chest wall tumor in 19 patients. Results: All surgical operations were successfully performed, without intraoperative death. The results of postoperative follow-up were asfollows: forty-eight patients with benign tumors were still living and healthy, 16 patients with benign tumors died of other diseases, 13 with malignant tumors survived for a period ranging from 21 monthsto 8 years, and the others with malignancy died of local recurrence or distant metastasis. All 11 patients with metastatic tumor died of carcinomatous diseases within 10 to 76 months. Conclusion: A restricted radical excision should be conducted first in cases of primary costal tumors without pathological diagnosis. Use of suitable repairing materials is very important for reconstruction of a large chest wall defect.