Abstract: Objective: To observe the curative effect and safety of mannatide combined with vi-norelbine and capecitabine on advanced breast cancer. Methods: 39 patients with metastatic advanced breast cancer were randomly divided into two groups. Control group(n=18) received vinorelbine 6mg/m/d,d1-5 civ,cycles were repeated every 21 days,also received capecitabine for 2-4 cycles at the sametime. In addition to the same regimen, treating group(n=21) accepted intravenous infusion of mannatide(10mg/d)for the first 3 days, then increased to the dose of 20mg/d for 8-12weeks. Results: In treatment and control groups, the effective rates were 58.2% and 44.4%(P<0.05), the rates of side effects in treat-ment group were less than in control group. Conclusions: Mannatide combined with vinorelbine andcapecitabine is effective for advanced breast cancer and can reduce the side effects of vinorelbine plus capecitabine.