Abstract: Objective: To investigate the expression of EZH2 and p53 in human breast carcinoma and their correlation with tumor progression. Method: A total of 44 cases of breast cancer tumor tissuewere detected for the expression of EZH2 and p53 by immunohistochemistry, and further analyzed their relationship and correlation with the clinical pathologic characteristics. Results: The EZH2 expression was detected in 48% (26/54) of tumor tissues and it's expression was correlated with the tumor size,lymph node metastasis, pathological grade and Estrogen Receptor(ER) level. In contrast, it did not show correlation with patient age, clinical stage and Progesteron Receptor (PR) level. The incidence of EZH2 expression in p53 positive group and p53 negative group was 64% (16/25) and 31%(9/29) respectively and this difference between two groups showed statistically significant(P=0.03). Conclusion: EZH2 wasover-expressed in breast carcinoma and its over- expression was correlates with expression of p53,which suggested that crosstalk between EZH2 and p53 may play an important role in tumorigenesis and metastasis in breast cancer.