术前紫杉醇化疗对肺腺癌组织Survivin表达和血管生成的影响

Effect of Preoperative Paclitaxel Chemotherapy on the Expression of Survivin and Angiogenesis in Lung Adenocarcinoma Tissues

摘要: 目的 :探讨术前紫杉醇(pacilitaxel,PTX)化疗对肺腺癌组织抗凋亡蛋白(Survivin)表达和血管生成的影响。方法 :2002年10月～2005年10月,对30例术前应用PTX化疗的肺腺癌和30例术前未化疗的肺腺癌组织(对照组),用免疫组织化学法,检测Survivin表达及肿瘤组织微血管密度(MVD)。结果 :术前PTX化疗组Survivin表达阳性率为33.3%,对照组为60.0%;术前PTX化疗组MVD值为37.4±18.0,对照组为65.8±12.5;两者均有显著性差异。结论 :术前PTX化疗能降低肺腺癌Survivin活性,抑制肺腺癌肿瘤血管生成。

Abstract: Objective :To study the effect of preoperative paclitaxel (PTX) chemotherapy on theexpression of survivin and angiogenesis in lung adenocarcinoma tissues. Methods :From October 2002to October 2005,30 cases with PTX preoperative chemotherapy and 30 cases without it (control group)were analyzed. Immunohistochemical staining was performed with survivin and CD34+ monoclonal anti-bodies to detect survivin expression and microvessel density (MVD). Results :The positive expressionrate of survivin was 33.3% and 60.0% in the chemotherapy group and the control group, respectively.MVD was 37.4± 18.0 in the chemotherapy group and 65.8± 12.5 in the control group (P<0.05). Conclu-Sion :Preoperative chemotherapy of PTX can decrease the activity of survivin and inhibit angiogenesisin lung adenocarcinoma.