Abstract: Objective : To explore the prognostic factors that influence the survival rate of patients with liver metastasis from colorectal cancer and analyze the significance of the these factors. Methods : Clinical and pathological data of 158 patients with liver metastasis from colorectal cancer were collected in this study. Univariate and multivariate analysis of 12 factors was used to determine the prognostic factors. Results : In these cases, radical resection, palliative resection and explorative operation/best supportive care were carried out in 67 patients (42.4%), 53 patients (33.5%)，and 38 patients (24.1%), respectively. Eighty -two patients (51.9%) received systemic chemotherapy after surgical resection and 76 patients (48.1%) did not. The positive and negative pathological margins were correlated with each other in 132 c^ses (83.5%) and 26 cases (16.5%)，respectively. The median overall survival was 41 months and the 5-year survival rate was 27%. Univariate analysis showed that the surgical treatment (P=0.013<0.05), N stage of the primary disease (P=0.003<0.05), secondary treatment (P=0.041 <0.05)，the size and distribution of the liver metastatic focus (P=0.037<0.05 and P=0.032< 0.05)，and the pathological margin (P=0.000<0.001) were predictors of survival. Regional lymph node metastatic status was a significant prognostic factor according to the multivariate analysis (P=0.004). Conclusion : Radical resection of hepatic metastases from colorectal cancer is considered the only effective therapy for long-term survival. Candidates for one-stage radical hepatic resection must be selected appropriately. Neoadjuvant chemotherapy should be followed by radical resection for patientsrate of radideemed unfit in order to improve the success cal resection and long-term survival.