Abstract: Objective: To explore early prediction of breast cancer metastasis to bone after surgery by studying the expression of BSP in primary tissues and levels of TRACP5b in the serum of patients who developed bone metastasis in the course of their disease after surgery. Methods: Immunohisto-chemistry method (S-P) was used to assess BSP expression in tissue samples from 35 cases of primary breast cancer. The levels of TRACP5b in serum samples from 35 patients with breast cancer with and without bone metastasis after surgery were measured using an ELISA. Results: Using Spearman corre-lation we found the expression of BSP was positively correlated with bone metastasis and the correlation coefficient was 0.439 (P<0.01), but we did not discover any correlation between serum levels of TRACP5b and bone metastasis (P>0.05). Conclusion: Early prediction of breast cancer metastasis to bone can be done using the traditional method of detecting serum TRACP5b levels, but it can be signif-icantly improved by examining BSP expression in the primary breast cancer tissues themselves in con-junction with serum TRACP5b detection.