马绍康, 吴令英, 高菊珍. 子宫内膜癌ⅢA期单纯腹腔液细胞学阳性术后辅助治疗的意义[J]. 中国肿瘤临床, 2007, 34(14): 822-825.
引用本文: 马绍康, 吴令英, 高菊珍. 子宫内膜癌ⅢA期单纯腹腔液细胞学阳性术后辅助治疗的意义[J]. 中国肿瘤临床, 2007, 34(14): 822-825.
Ma Shaokang, Wu Lingying, Gao Juzhen. The Significance of Postoperative Adjunctive Therapy for Positive Peritoneal Cytology in Stage IIIA Endometrial Carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2007, 34(14): 822-825.
Citation: Ma Shaokang, Wu Lingying, Gao Juzhen. The Significance of Postoperative Adjunctive Therapy for Positive Peritoneal Cytology in Stage IIIA Endometrial Carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2007, 34(14): 822-825.

子宫内膜癌ⅢA期单纯腹腔液细胞学阳性术后辅助治疗的意义

The Significance of Postoperative Adjunctive Therapy for Positive Peritoneal Cytology in Stage IIIA Endometrial Carcinoma

  • 摘要: 目的 :评价子宫内膜癌单纯腹腔液细胞学阳性患者术后辅助治疗的意义。 方法 :回顾性分析37例单纯腹腔液细胞学阳性而无宫外转移的ⅢA期患者术后辅助治疗情况。 结果 :37例单纯腹腔液细胞学阳性患者分为3组;1)高危组包括14例深肌层浸润及4例浆液性乳头状腺癌患者;2)低危组术后辅助治疗患者9例;3)低危组术后未接受辅助治疗患者10例。术后辅助治疗包括单纯放疗、单纯化疗、放疗联合化疗。本组共有5例复发,总复发率13.5%(5/37)。术后辅助治疗者4例复发,复发率14.8%(4/27),其中2例为浆乳癌患者;术后无辅助治疗者1例复发,复发率10.0%(1/10)。寿命表法计算5年生存概率,37例患者总的5年生存率为71.5%。术后无辅助治疗者73.0%,术后给予辅助治疗者68.1%,二者无显著性差异(P>0.05)。高危组术后辅助治疗的患者5年生存率为63.4%,低危组术后辅助治疗的患者5年生存率为74.3%。具有高危因素的患者与不具有高危因素的患者相比,无论术后是否进行辅助治疗其5年生存率低,有显著性差异(P<0.05)。术后单纯放疗者5年生存率66.7%,术后单纯化疗者63.7%,二者无显著性差异(P>0.05);术后放疗联合化疗者75.0%,与单纯放疗或单纯化疗者比较,有显著性差异(P<0.05)。 结论 :子宫内膜癌单纯腹腔液细胞学阳性对预后的影响不显著,具有高危因素的患者即使术后辅助治疗其预后也较差,不具高危因素的患者术后是否进行辅助治疗对生存率无明显影响。

     

    Abstract: Objective : To determine the value of postoperative adjuvant therapy for endometrial carcinoma in patients with positive peritoneal washing cytology. Methods: Thirty-seven patients with stage IQ A endometrial carcinoma who had positive peritoneal cytology were analyzed retrospectively. Results : The patients were divided into 3 groups as follows: 18 patients were in the high-risk group that included 14 patients with deep myometrial invasion and 4 patients with papillary serous carcinoma, 9 patients were in a low-risk group and received adjuvant therapy after surgery, and 10 patients were in a second low-risk group and received no treatment after surgery. Adjuvant therapy after surgery con-sisted of radiotherapy alone, chemotherapy alone or radiotherapy combined with chemotherapy. Recur-rence occurred in 5 of 37 patients (13.5%). Four of 27 patients (15.8%) who received adjuvant therapy and 1 of 10 patients (10%) with low-risk disease who received no adjuvant treatment had recurrence. The overall accumulated 5-year survival rate of the 37 patients was 71.5%. The accumulated 5-year survival rate in patients who received or did not receive adjuvant therapy was 68.1% and 73%, respec-tively. The 5-year survival rates of patients with low—risk disease who did and did not receive adjuvant therapy post-operatively were 74.3% and 73%, respectively. The 5-year survival rate of patients with high-risk disease was 63.4%, which was lower than the 5-year survival rate of patients with low-risk disease regardless of whether or not they received postoperative adjuvant therapy. The 5-year survival rate of patients who received radiation alone or chemotherapy alone was 66.7% and 63.7%, respectively. The 5 -year survival rate of patients who received radiotherapy combined with chemotherapy was 75%, significantly higher than that found with radiation or chemotherapy alone. Conclusion : Postoperative adjuvant treatment for patients with low- to moderate-risk stage IIIA endometrial carcinoma with positive peritoneal cytology seems to have no effect on the prognosis.

     

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