Abstract:
Objective :To investigate the factor (s) that can accurately predict the prognosis of FI-GO Ib cervical squamous cell carcinoma treated with radical surgery.
Methods :The clinical data of174 cases of FIGO Ib cervical squamous cell carcinoma treated in the Department of Gynecologic On-cology in the Cancer Center of Sun Yat-sen University were analyzed.
Results :The overall 5-year dis-ease-free survival rate for all patients was 79.4%, and the recurrence rate was 16.7%. 75.0% patientswith tumors >4cm(60 cases) and 28.1% patients with tumors ≤4cm(114cases) received preoperative ra-diation. There was no significant difference in 5-year disease-free survival rate among cases with tu-mors ≤4cm with no preoperative radiation(80.5%), tumors ≤4 cm with preoperative radiation(85.2%),tumors >4cm with no preoperative radiation (69.3%) and tumors >4cm with preoperative radiation(77.1%)(P>0.05). Univariate analysis showed pelvic node metastasis, positive parametrial surgical mar-gin and postoperative adjuvant therapy were significantly correlated with 5-year disease-free survivalrate (P<0.05). Multivariate analysis revealed that pelvic node metastasis (P=0.004) and positive parame-trial surgical margin (P=0.040) were independent factors that influenced prognosis. In the high riskgroup (patients with pelvic node metastasis and/or positive parametrial surgical margin), there was nosignificant difference in 5-year disease-free survival rate (57.4% vs. 44.7%, P=0.575) or recurrencerate (7/18 vs. 6/14, P=0.821) between those with tumors ≤4cm and those with tumors > 4cm. In thelow risk group (patients without node metastasis or positive parametrial surgical margin), there was a-gain no significant difference in 5-year disease-free survival (86.5% vs. 82.9%, P>0.05) or recurrencerate (9/95 vs. 7/47, P>0.05) between patients with tumors ≤4cm and those with tumors > 4cm.
Con-Clusion :For FIGO Ib cervical squamous cell carcinoma treated primarily with radical surgery, pelvicnode metastasis and positive parametrial surgical margin are independent factors that influence progno-sis, while tumor size doesn't provide valuable prognostic information.