Abstract: Objective :To explore the clinical efficacy of high intensity focused ultrasound (HIFU)treatment for residual hepatic tumor after radiofrequency treatment. Methods :Six patients with residualhepatic tumors of different shapes and sizes after radiofrequency treatment received HIFU treatment andpartial costectonmy. MRI was used to evaluate the therapeutic effect of HIFU. Seven to fourteen daysafter HIFU treatment, vital signs and main organ functions were observed. Results :All of the patientstolerated costectomy and HIFU treatment well. The patients' vital signs were stable during the treatmentand within 48 hours after the treatment. Dynamic MRI examination showed a complete ablation of theresidual tumors in all of the patients. During follow-up, all of the patients survived, disease free, for 6-21 months. Conclusion :HIFU is a safe, effective and noninvasive treatment for hepatic tumors.