Abstract: Objective :To observe and compare the therapeutic efficacy and adverse side effects ofpaclitaxel and oxaliplatin (L-OHP) combined with 5-fluorouracil/leucovorin (5-FU/CF) in the treatmentof patients with advanced gastric cancer (AGC). Methods :A total of 56 patients with AGC were ran-domized into two groups. Two or more cycles of chemotherapy were completed. Group A consisted of 27patients who received paclitaxel plus 5-FU/CF and group B consisted of 29 patients who received ox-aliplatin plus 5-FU/CF. Results :In group A and B, the response rate (CR +PR) was 59.26% and55.17%, the median duration of the therapeutic effects was 5.8 and 6.2 months, and the median sur-vival of patients was 11.6 and 10.8 months, respectively. The most common side effects in both groupswere myelosuppression, mild neuro-sensory toxicity and sensitivity of the gastrointestinal tract. Com-pared with patients in group A, patients in group B experienced milder myelosuppression and more se-rious diarrhea. Conclusion :The effects of paclitaxel or L-OHP combined with 5-FU/CF are compara-ble. The adverse side effects are mild and patients tolerate the chemotherapy well.