杨洁, 卢文娜. 国产吉西他滨与奈达铂治疗晚期非小细胞肺癌近期疗效观察[J]. 中国肿瘤临床, 2006, 33(18): 1044-1046.
引用本文: 杨洁, 卢文娜. 国产吉西他滨与奈达铂治疗晚期非小细胞肺癌近期疗效观察[J]. 中国肿瘤临床, 2006, 33(18): 1044-1046.
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Yang Jie, Lu Wenna. The Observation of Short Term Efficacy in Combined Therapy with Gemcitabine and Nedaplatin in Treatment of Advanced Non-small Cell Lung Cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2006, 33(18): 1044-1046.
Citation: Yang Jie, Lu Wenna. The Observation of Short Term Efficacy in Combined Therapy with Gemcitabine and Nedaplatin in Treatment of Advanced Non-small Cell Lung Cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2006, 33(18): 1044-1046.
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国产吉西他滨与奈达铂治疗晚期非小细胞肺癌近期疗效观察

The Observation of Short Term Efficacy in Combined Therapy with Gemcitabine and Nedaplatin in Treatment of Advanced Non-small Cell Lung Cancer

    摘要
  • 摘要: 目的 :观察国产吉西他滨(gemcitabine GEM)与奈达铂(nedaplatin NDP)联合化疗治疗晚期非小细胞肺癌(non-smallce lllungcancer NSCLC)的临床疗效及不良反应。 方法 :32例均为不能手术的Ⅲ～Ⅳ期非小细胞肺癌患者。吉西他滨1000mg/m2静脉滴注,第1、8或15天,奈达铂80mg/m2第1天。每21天或28天为1个周期,治疗3～4周期。 结果 :全组无完全缓解的患者,总有效率为46.8%(14/32)。中位生存期为325天,1年生存率为32.1%。主要不良反应为骨髓抑制及恶心、呕吐,但无严重的Ⅳ度损害;无1例因毒性反应而延期化疗。 结论 :吉西他滨加奈达铂联合化疗治疗晚期非小细胞肺癌有较好的疗效,且耐受较好。

     

    Abstract: Objective :To observe clinical effect and adverse effect of the combined therapy of gemcitabine with nedaplatin for advanced NSCLC. Methods :A total of 32 patients were pathologically confirmed as stage Ⅲ or Ⅳ NSCLC missing opportunity of surgical operation.Gemcitabine was given on day 1,8 or 15 at a dose of 1000mg/m2 and nedaplatin on days 1 at a dose of 80mg/m2.The chemotherapy was repeated every 21 or 28 days up to 3~4 cycles. Results :No complete response occurred in the patients and the overall response rate was 46.8%.The median survival time was 325 days and the 1-year survival rate was 32.1%.The main adverse effects were myelosuppression,nausea and vomiting.However,there was no severe grade-Ⅳ damage.No treatment with chemotherapy was delayed due to adverse effect. Conclusion :The combined therapy with gemcitabine and nedaplation is effective and well tolerated in treatment of the advanced NSCLC.

     

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