Abstract: Objective :To investigate and stratify the prognostic factors of cervical squamous cellcarcinoma according to the corresponding prognostic risks and to establish a prognosis-predictive sys-tem. Methods :The clinicopathological data and follow-up results of 287 cases of cervical squamouscell carcinoma were analyzed. The prognostic factors were identified and stratified by univariate andmultivariate analysis. Results :The 5-year disease-free survival (DFS) rate was 81.3% for the 287cases. Multiple Cox regression analysis identified pelvic node metastasis (P<0.001), positive parametrialsurgical margin (P=0.013) (class A factors) and deep stromal invasion (P=0.035) (class B factor) as prog-nostic factors. Local recurrence, local recurrence plus distant metastasis and distant metastasis wereseen in 27.4%, 4.1% and 13.7% of patients with class A factor(s), 20.0%, 1.1% and 1.1% of those withclass B factors, and 9.2%, 1.7% and 0.8% of the patients with neither class A nor class B factors, re-spectively. A prognosis-predictive system based on class A and class B factors was established. Patientswith class A factor(s) were divided into the high risk group with 5-year DFS rate ranging from 25.0% to61.3%, patients with class B factors were in the intermediate risk group with a DFS rate of 83.7%,while patients with neither A nor B factors were in the low risk group with a DFS rate of 93.9%. Con-Clusion :Pelvic node metastasis, positive parametrial surgical margin, and deep stromal invasion are fac-tors that influence the prognosis of squamous cell carcinoma of the cervix. Patients with the above fac-tors have various levels of prognostic risk and different patterns of recurrence, therefore individualizedtreatment should be considered.