Abstract: Bone is a common site of cancer metastasis. Complications of skeletal metastasis in-clude pathological fractures, hypercalcemia, spinal cord compression, and bone pain. These conditionshave a profound impact on patients' quality of life and lead to impaired mobility. Therefore, the study ofskeletal metastasis has been an important topic in carcinoma treatment. Bone metastasis can be classi-fied into osteolytic, osteoblastic, and mixed, according to the primary mechanism of interference withnormal bone remodeling. The main mechanism of osteoblastic metastasis involves cytokines which stim-ulate bone formation and osteoblast proliferation in the bone microenvironment. Osteoblastic metastasiscan be detected by bone scanning, X-ray, CT and MRI. The treatment for osteoblastic metastasis in-cludes chemotherapy, endocrine therapy, external radiation, internal radiation, surgery, and administra-tion of bisphosphonates and analgesics. These therapies should be combined to achieve the best results.