Abstract: Objective: To detect the expression of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) and to determine its significance in breast cancer. Methods: EGFR and VEGF expression was detected by immunohistochemistry in 86 breast cancer tissues and 46 adenoma tissues, and their relationship was analyzed. Results: The positive rates of EGFR and VEGF expression were 13.04%(6/46) and 34.78%(16/46), respectively, in breast adenoma tissues and 56.98% (49/86) and 54.65%(47/86), respectively, in breast cancer tissues. No significant difference was found between EGFR expression and VEGF expression (P>0.05). The positive rates of EGFR and VEGF in breast cancer tissues were higher than those in adenoma tissues(P<0.05). The positive rates in the infil-trating cancer group (infiltrating lobular carcinoma and ductal carcinoma) were higher than those in the non- infiltrating group (lobular carcinoma in situ and intraductal carcinoma)(P<0.05). The positive rates of EGFR and VEGF in the group with lymph node metastasis were higher than those in the group without lymph node metastasis (P<0.05). Conclusion: The expression of EGFR and VEGF is positively correlated to breast cancer occurrence and lymph node metastasis. The detection of EGFR and VEGF is helpful for targeted chemotherapy.