Abstract: Objective: To retrospectively analyze the long-term treatment outcome of 64 cases of early primary nasal NK/T-cell lymphoma and to explore the prognostic factors. Methods: From July 1993 to October 2005, 64 cases of nasal NK/T-cell lymphoma were diagnosed and confirmed pathologically in our hospital. Data from these patients were retrospectively reviewed. According to the Ann Arbor staging classification, the 64 patients belong to stage ⅠE/ⅡE. Twenty-three patients received radiotherapy alone, and the other 41 cases received chemotherapy combined with radiotherapy. Kaplan-Meier methods were applied in unifactorial analysis, and the Cox regression model was applied in multivariate analysis. Results: The median overall survival time was 41 months, and the 5-year overall survival (OS) rate was 59.17%. Those who received radiotherapy alone had a 5-year OS rate of 57.86% and for those who received radiotherapy combined with chemotherapy the 5-year OS rate was 61.45%. No significant difference was found (P=0.47). Multivariate analysis showed that Eastern Cooperative Oncology Group(ECOG) performance status (PS) score ≥2, local tumor invasion out of the nasal cavity and lower complete response rate to the primary treatment were significant unfavorable independent prognostic factors. Conclusion: Chemotherapy combined with radiotherapy does not improve the survival of patients with early stage nasal NK/T-cell lymphoma. PS score before treatment, local tumor invasion out of the nasal cavity, and complete response rate to the primary treatment are independent prognostic factors.