Abstract: Objective: To evaluate the efficacy of postoperative concurrent radiochemotherapy for high grade intracranial glioma. Methods: Sixty- two patients who underwent surgery for intracranial glioma were randomly grouped into the observation group (n=32) and the control group (n=32). In the control group, routine postoperative external irradiation was administered in a total dose of 58~62Gy/6weeks. The patients in the observation group received chemotherapy and radiotherapy concurrently.The irradiative dose was 20 to 30Gy and Me- CCNU was given at 150mg orally, once every six to eight weeks for 4 to 6 cycles. Results: The local response rate was 68.75% in the observation group and 25% in the control group, with a significant difference (P<0.01). Median recurrent time was 14.25 months in the observation group and 10.38 months in the control group (P<0.01). The 1-, 2-, 3- year survival rates were 71.88%, 43.75%, and 21.88% in the observation group and 50%, 15.63%, and 9.38% in the control group. A significant difference was found in 2- year survival rate between the two groups(P<0.05). The acute toxicity was more serious in the observation group. The late toxicity was similar in both groups. Conclusion: Postoperative concurrent radiochemotherapy can improve the local control rate and prolong the recurrent time of patients with high grade intracranial glioma.