Abstract: Objective: To enhance the understanding of Castleman's disease (CD) and to improve its diagnosis and management. Methods: Clinical features and related information on diagnosis and treatment of 14 cases of CD were retrospectively analyzed and the related literature was reviewed. Results: Based on the clinical classification, localized CD was found in 8 of the 14 cases. The results of lymph node biopsy and histopathology both indicated they were of hyaline-vascular type. Multicentrictype CD was detected in 6 cases, among which 4 were plasma cell type and 2 were mixed type based on histopathologic examination. The clinical manifestations were different and not specific in the 14 cases. They were previously misdiagnosed as other diseases, and the final diagnosis depended on histopathologic examination. The 8 patients with localized CD underwent surgery, and there was no recurrence during the follow-up period. The 6 patients with multicentric-type CD were treated with glucocorticoids or combined chemotherapy, and all achieved remission. Conclusion: CD has complicated clinical manifestations and is difficult to diagnose. Lymph node biopsy is important for early diagnosis. An optimal curative effect can be achieved through a suitable therapeutic option that is based on histopathology and clinical classification.