Abstract: Ezrin protein, a member of the ERM (Ezrin/Radixin/Moesin) family, is a linking protein between cytoskeleton and plasma membrane that regulates the structure and function of the plasma membrane and maintains its stability. Ezrin protein is involved in the formation of microvilli, the maintenance of cell morphology, cell movement and adhesion, reorganization of cytoskeleton and signal transduction. It links plasma membrane molecules such as CD43, CD44, E- cadherin, and ICAM- 1 to F- actin. Recent research suggests that Ezrin protein is an important factor in the genesis, metastasis and prognosis of many kinds of tumors such as gynecological tumors, digestive canal tumors, melanoma,nasopharyngeal carcinoma, adult soft connective tissue tumor, pediatric osteosarcoma,rhabdomyosarcoma and so on. The abnormal expression of Ezrin protein in tumor cells may correlate with increased metastasis. Recent advances in understanding the relationship between Ezrin protein and cancer metastasis are reviewed in this article.