Abstract:
Objective To analyze clinical laboratory characteristics of patients with gastric cancer with bone marrow invasion and screen laboratory indexes with clinical significance.
Methods Clinical data of blood routine tests, coagulation function, immunity, biochemistry, and bone marrow detection of 30 patients with gastric adenocarcinoma with bone marrow invasion in The Fourth Hospital of Hebei Medical University from January 2013 to March 2021 were collected. Differences in clinical laboratory test results of patients with gastric cancer with bone marrow invasion and those with stage IV gastric cancer without bone marrow invasion were analyzed. Furthermore, receiver operating characteristic (ROC) curves were developed to evaluate the significance of each indicator in predicting gastric cancer with bone marrow invasion.
Results The values of Plt, PT, TT, LDH, D-DMER, FDP, CEA and CA72-4 in patients with bone marrow invasion were significantly different from those in patients with stage IV gastric cancer without bone marrow invasion (P<0.05). The area under the ROC curve of FDP was the largest (AUC=0.988), and the positive likelihood ratio was the highest. Moreover, there was significant difference between the two patient groups with respect to the detection rate of nucleated red cells and immature granular cells in peripheral blood (P<0.01).
Conclusions Several clinical laboratory parameters of patients with gastric cancer with bone marrow invasion have higher abnormal detection rates and more obvious changes than those of patients with gastric cancer without bone marrow invasion. These indicators have certain suggestive significance for gastric cancer invading the bone marrow.
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