Abstract: Interleukin-35 (IL-35) is a newly discovered heterodimeric cytokine that belongs to the IL-12 family. IL-35 is one of the three most important immunosuppressive factors, along with transforming growth factor-β (TGF-β) and IL-10. IL-35 is expressed in various immune and tumor cells. In recent years, several studies have shown that in addition to having an immunosuppressive effect on malignant tumors, IL-35 plays an important role in tumor cell proliferation, apoptosis, invasion and migration, and angiogenesis. Tumor angiogenesis is indispensable to the development of solid tumors. This article analyzes and summarizes the role of IL-35 in tumor angiogenesis, acting as a reference for clinical and basic research.