Abstract: N⁶-methyladenosine (m⁶A) modification are one of the most common epigenetic modifications found in eukaryotic mRNA, and it is known to affect several biological processes. It mainly affects the intracellular RNA levels via modification of mRNA in the cell, and these changes can play a key role in disease progression and tumorigenesis. In recent years, many studies have found that m⁶A RNA modification related factors are abnormally expressed in gastric cancers. The m⁶A modifications result in increased proliferation, risk of metastasis and invasion, apoptosis as well as drug resistance of gastric cancer cells. In this study, we systematically review the diverse role of m⁶A modifications in the pathogenesis and chemotherapy resistance of gastric cancer.