Abstract: Supportive care is equally important as radiotherapy, chemotherapy, and surgery in cancer treatment. The content of supportive care in cancer is quite broad and includes the entire process from the beginning of tumor diagnosis to the end of patients’ life. Effective tumor supportive care is helpful in prolonging patients’ survival, improving their quality of life, and decreasing medical costs. In recent years, with the advances in clinical and basic research, a series of important progress has been made in various areas of supportive care in cancer, and its role has attracted further attention. It is particularly important that the cognition of doctors and patients has fundamentally changed from the traditional treatment concept, making the development of supportive care a topical need. Currently, supportive care is gradually being developed toward multidisciplinary integration, patient-centered individualization, whole-process management, and digitalization. In the future, with the refinement of discipline branches and the deepening of basic translational research, supportive care in cancer will form an integrated system, from which more patients with cancer would benefit.