Abstract: The skeletal system is a common site for distant metastasis in patients with breast cancer, which accounts approximately 60%-75% of all metastatic breast cancers. Compression induced by the metastatic lesions on the neurovascular bundle often leads to a severe loss of the sensory and motor functions in the afflicted limb, including skeletal-related events (SREs), such as bone pain, pathologic fractures, and hypercalcemia spinal cord compression. The quality of life (QOL) of the patients is severely affected. Early diagnosis and timely intervention improve the QOL of patients with breast cancer and bone metastasis and reduce cancer-related mortality. The Bone Tumor and Bone Metastasis Committee of Chinese Anti-Cancer Association proposed this study titled “Expert consensus on the diagnosis and treatment of bone metastasis in patients with breast cancer,” as a clinical reference for the orthopedic oncologists.