Abstract: Gastric cancer is a common malignant tumor worldwide. In China, both the morbidity and mortality rates of gastric cancer rank third. Recently, with the improvement of diagnostic technology and screening implementation, the 5-year survival rate of patients with gastric cancer has gradually increased; however, it remains at a low level compared to that of Japan, South Korea, and other developed countries. Therefore, a guideline with Chinese characteristics for the prevention and treatment of gastric cancer is immediately needed. The integrative guideline of gastric cancer was accomplished by the Society of Gastric Cancer under the guidance of the China Anti-Cancer Association (CACA). This is the most comprehensive guideline, which incorporated the discipline system of gastric cancer. Adhering to the concept of the “whole person, whole body, whole process, and holographics,” we focused on the overall process management of preventing, screening, diagnosing, treating, and rehabilitating, which embodies the integration of discipline and technology and concepts of multi-disciplinary team to holistic integrative medicine (MDT to HIM). The guideline focused on the Chinese epidemiology, genetic background, and characteristics of diagnosis and prevention, included the Chinese original studies and medical accessibility, highlighted the traditional Chinese medicine and history, and reflected the integration of study evidence, doctor experience, and patient needs. The guideline recommended that the management project with greater evidence, better accessibility, and higher clinical practice guidance value in China, which can be more pertinent for prevention and treatment, may improve the prognosis of patients with gastric cancer and contributes to conduct the “Healthy China Initiative.”