18F-FDG PET/CT和MRI及血浆EB病毒水平对鼻咽癌局部复发的诊断价值研究

Diagnostic value of 18F-fluorodeoxyglucose positron emission computed tomography, magnetic resonance imaging, and plasma EBV levels on local recurrence of nasopharyngeal carcinoma

    摘要
  • 摘要:
      目的  比较18F-FDG PET/CT、MRI在鼻咽癌局部复发和放疗后改变的鉴别诊断中的应用价值，并确定更合适的SUVmax诊断阈值，探索血浆EBV-DNA在发现鼻咽癌复发转移方面的意义。
      方法  选取2015年1月至2020年2月期间放疗结束至少6个月后在福建省肿瘤医院进行复查的鼻咽癌患者208例，均进行MRI、PET/CT及EB病毒DNA检查（均在1个月内完成）。以活检病理结果或影像学的密切随访（至少1年）作为诊断鼻咽癌是否局部复发的标准，对患者的影像检查结果及相关参数进行比较分析。
      结果  共有83例患者确诊为鼻咽癌局部复发，125例确诊为无局部复发，后者中77例伴有区域复发和（或）远处转移。PET/CT和MRI对鼻咽癌局部复发的诊断敏感性、特异性、准确性分别为89.2% vs. 67.5%，90.4% vs. 92.0%，89.9% vs. 82.2%。当诊断临界值SUVmax=3.85时，PET/CT的诊断准确性最高，与SUVmax=2.5相比，特异性（89.6% vs. 68.0%）和准确性（89.4% vs. 78.4%）均有显著提升。对纳入患者中治疗失败患者的EB病毒DNA分析发现，局部复发患者的血浆EBV-DNA检测敏感性低于区域复发或远处转移患者。局部复发肿瘤患者的SUVmax值与血浆EBV-DNA存在相关性。
      结论  18F-FDG PET/CT对鼻咽癌局部复发和放疗后改变的鉴别诊断效能优于MRI。SUVmax诊断阈值设为3.85时可获得更好的诊断效能。血浆EBV-DNA检测在鼻咽癌区域复发和远处转移方面较灵敏，局部复发者的阳性率并不高，对这部分患者的诊断价值仅提供参考。

     

    Abstract:
      Objective  To compare the application value of 18F-fluorodeoxyglucose positron emission computed tomography (18F-FDG PET/CT) and magnetic resonance imaging (MRI) in the differential diagnosis of local recurrence and post-radiotherapy changes in nasopharyngeal carcinoma (NPC); to determine a more appropriate diagnostic threshold for maximum standardized uptake value (SUVmax); and to explore the significance of plasma EBV-DNA in detecting recurrent metastases in NPC.
      Methods  Patients with NPC, who underwent review at Fujian Cancer Hospital between January 2015, and February 2020, 6 months after the end of radiotherapy, underwent MRI, PET/CT, and EBV DNA examinations (all within a month). Close follow-up (at least 1 year) of their biopsy pathology results or imaging was used as basis to verify whether NPC was locally recurrent. The patients' imaging findings and related parameters were compared and analyzed.
      Results  A total of 83 patients were diagnosed with a local recurrence of NPC. Besides, 125 were diagnosed without local recurrence. Seventy-seven of the patients without local recurrence had a regional recurrence and/or distant metastases. The sensitivity, specificity, and accuracy of PET/CT and MRI for local recurrence of NPC were 89.2% vs. 67.5%, 90.4% vs. 92.0%, and 89.9% vs. 82.2%, respectively. The diagnostic accuracy of PET/CT was highest when the diagnostic threshold SUVmax=3.85. The specificity (89.6% vs. 68.0%) and accuracy (89.4% vs. 78.4%) significantly improved compared with a SUVmax=2.5. Analysis of EBV-DNA from patients with treatment failure revealed that plasma EBV-DNA detection sensitivity was lower in patients with local recurrence than in patients with regional recurrence or distant metastases. This highlights the correlation between SUVmax values and plasma EBV-DNA in patients with locally recurrent tumors.
      Conclusions  18F-FDG PET/CT is more effective than MRI for the differential diagnosis of local recurrence and post-radiation changes in NPC. Better diagnostic efficacy is obtained when the SUVmax diagnostic threshold is set at 3.85. Plasma EBV-DNA testing is more sensitive in regional recurrence and distant metastasis of NPC. Still, the positive rate in those with local recurrence is not high, and the diagnostic value for this group should only be used as a reference.

     

    • HTML全文
    • 参考文献(18)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回