Objective  To explore the relationship between the single nucleotide polymorphisms (SNPs) rs12958604 and rs10502913 of SMAD4 gene and susceptibility to cervical cancer.

  Methods  The blood samples and related clinicopathological data of 342 cervical cancer patients and 342 healthy individuals diagnosed in Affiliated Hospital of Youjiang Medical University for Nationalities and Guangxi Medical University Cancer Hospital from February 2018 to December 2019 were collected and assigned into cervical cancer group and control group. DNA sequencing and SNaPshot detection were used to analyze and compare the differences between rs12958604 and rs10502913 genotypes, alleles, gene models, and haplotypes between the two groups.

  Results  The differences in genotype and allele frequencies in rs10502913 between cervical cancer patients and healthy individuals had no statistical significance (P>0.05). There were significant differences in the rs12958604 GG genotype, GG+GA dominant model, and G allele between the two groups (OR=0.577, 95%Cl: 0.380-0.877, P=0.010; OR=0.670, 95%Cl: 0.483-0.928, P=0.016; and OR=0.743, 95%Cl: 0.600-0.920, P=0.006). Haploid analysis showed that there were statistically significant differences between G-A and G-G between the two group (P<0.05). Multivariate Logistic regression analysis showed that hypertension was an independent risk factor.

  Conclusions  There may exist a correlation between rs12958604 and susceptibility to cervical cancer.