Abstract: Indocyanine green (ICG) near-infrared imaging technology has significant research value in laparoscopic radical gastrectomy and has garnered widespread attention and research both domestically and internationally. However, the application of ICG near-infrared imaging technology in laparoscopic radical gastrectomy is still in the exploratory stage in current clinical practice, with no unified standards established as yet. This review introduces the mechanism of ICG fluorescence imaging and discusses the indications and contraindications of ICG use in laparoscopic radical gastrectomy. The application methods and procedures of ICG molecular fluorescence imaging technology in laparoscopic radical gastrectomy and its clinical applications are elaborated upon. Finally, the practical applications of ICG-guided laparoscopic radical gastrectomy is summarized and generalized to help facilitate its promotion and further standardization.