Abstract: Chemical modifications of nitrogenous bases or ribosemoieties are common in RNA molecules and these RNA modifications regulate tumor progression by modulating gene expression in malignancies. Therefore, delving into the role of RNA modifications in tumor progression is essential for understanding tumor progression mechanisms and developing intervention strategies. Mitochondria are crucial for maintaining the energy state of malignant tumor cells. Recent studies have indicated that RNA modifications and tumor mitochondria are closely connected, implying that mitochondrial function within tumors can be disrupted due to RNA modifications. This article focuses on the role and underlying mechanisms of RNA modifications in tumor mitochondria, offering crucial insights for a deeper understanding of the regulatory mechanisms of tumor metabolism and the development of new innovative therapeutic strategies.