Abstract: Autophagy is a cellular self-degradation process essential for maintaining metabolic functions in cells and organisms. Dysfunctional autophagy has been linked to various diseases, including cancer. The m⁶A modification, a major RNA modification in eukaryotes, plays a crucial role in regulating autophagy in tumor cells by regulating the expression of autophagy-associated genes (ATGs) or interfering with autophagy-related signaling pathways. Aberrant m⁶A modification can lead to dysregulated autophagy and impact tumor progression. However, the specific role of m⁶A in regulating tumor autophagy remains to be explored. Therefore, in this review, we discuss the role of m⁶A modification in tumor cell autophagy and examine its relationship with tumor progression and drug resistance, aiming to provide a theoretical foundation for developing new therapeutic strategies.