影响宫颈癌患者生育力因素的研究进展

Research progress on factors affecting fertility in patients with cervical cancer

  • 摘要: 在新诊断为子宫颈癌的患者中,许多患者均处于生育期,甚至未婚未育,面对年轻的宫颈癌患者,在抗肿瘤的同时如何保留生育功能是一项全新的课题和挑战。传统的手术、放疗、化疗在治疗疾病的过程中也对年轻患者的生育功能造成不可逆的损伤。伴随着辅助生殖技术的飞速发展,以及各种保留生育功能手术的创新改进和低卵巢毒性化疗方案的临床应用,使得早期宫颈癌患者的生育力保存成为标准治疗。但对于多数需接受放射治疗的宫颈癌患者而言,辐射导致卵巢损伤尚可通过精确放疗来减轻甚至避免,作为放疗靶器官的子宫的损伤情况,可能是制约宫颈癌放疗患者保存生育力的关键所在。本文就保留宫颈癌患者生育力方面的研究现状进行综述,以期为接受保育手术后放疗以及根治性放疗的宫颈癌患者生育力保护的临床诊疗方式的改良提供研究思路。

     

    Abstract: Among patients newly diagnosed with cervical cancer, many are fertile, and many are unmarried. Preserving fertility while treating cancer is a challenge in young patients with cervical cancer. Traditional surgery, radiotherapy, and chemotherapy cause irreversible damage to the fertility of young patients. Therefore, accompanied by the rapid development of assisted reproductive technology, innovation and improvement of various fertility-preserving surgeries, and development and application of chemotherapeutic agents with low ovarian toxicity, fertility preservation has become the standard of care for patients with early stage cervical cancer. For most patients with cervical cancer who need to undergo radiotherapy, radiation-induced ovarian damage can be reduced or even avoided by accurate implementation of precise radiotherapy. However, the damage to the uterus, which is the target organ of radiotherapy, may be the key constraint to fertility preservation in patients with cervical cancer undergoing radiotherapy. This study provides a review of the research progress on preserving fertility in patients with cervical cancer, aiming to provide research ideas for improving the clinical management of fertility preservation in patients with cervical cancer who receive postoperative conservation or radical radiotherapy.

     

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