Abstract:
Objective This study aimed to evaluate the prognostic factors of clinical and histopathological parameters, including age, gender, tumor stage, tumor grade, tumor differentiation, lymph node metastasis (LNM), tumor frequency, and tumor count, in patients undergoing radical cystectomy (RC) combined with Mainz PouchⅡ bladder reconstruction.
Methods A total of 237 bladder cancer patients (198 male and 39 female) who underwent RC combined with Mainz Pouch Ⅱ bladder reconstruction without chemotherapy or radiotherapy, from January 2004 to January 2023, were included in this study. Kaplan-Meier and Cox regression analyses were performed to assess the impact of age, tumor grade, tumor stage, tumor differentiation, LNM, tumor frequency, and tumor count on 5-year overall survival (OS) and 5-year cancer-specific survival (CSS).
Results The mean age at diagnosis was 59.8 years, with 198 male and 39 female patients. The mean follow-up duration was 47.8 months. In univariate analysis, patients younger than 65 years had significantly higher 5-year OS and 5-year CSS compared to those aged ≥65 years. Patients with urothelial carcinoma showed better 5-year OS than those with non-urothelial carcinoma. Additionally, tumor stage, tumor grade, and LNM were negatively associated with 5-year OS and 5-year CSS. On multivariate analysis, only tumor grade and LNM remained statistically significant (P<0.05).
Conclusions Tumor grade and LNM were identified as independent prognostic risk factors for 5-year OS and 5-year CSS following RC combined with Mainz PouchⅡ bladder reconstruction. Moreover, the application of RC combined with Mainz Pouch Ⅱ bladder reconstruction should consider the patient’s preferences and physical condition.
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