M1/M2型巨噬细胞影响口腔鳞癌进展的功能研究

Functional study of M1/M2 macrophages in the progression of oral squamous cellcarcinoma

    摘要
  • 摘要:
    目的 探索M1/M2型巨噬细胞对口腔鳞状上皮细胞癌（oral squamous cell carcinoma，OSCC）进展的调控及可能机制，以期为OSCC预后判断及生物治疗靶向提供可能方向。
    方法 检测M1/M2型巨噬细胞对SCC-15细胞增殖、迁移、侵袭、凋亡的作用；免疫组织化学染色方法检测人OSCC组织芯片中CD68及M2型巨噬细胞标记蛋白的表达情况，分析其与临床病理特征之间的关系。
    结果 M1型巨噬细胞促进SCC-15细胞的凋亡，抑制其增殖、迁移及侵袭能力，M2型巨噬细胞则作用相反；肿瘤相关巨噬细胞在OSCC中浸润密度，与肿瘤是否有淋巴结转移呈正相关，差异具有统计学意义（P<0.05）。
    结论 M1型巨噬细胞抑制OSCC进展，M2型巨噬细胞则促进OSCC进展。

     

    Abstract:
    Objective  This study aimed to identify potential prognostic and biotherapeutic targets for oral squamous cell carcinoma (OSCC) by investigating the regulatory effects of M1/M2 macrophages on OSCC progression and their underlying mechanisms.
    Methods  The effects of M1/M2 macrophages on the proliferation, migration, invasion, and apoptosis of SCC-15 cells were examined. Immunohistochemical staining was used to detect the expression of CD68 and M2 macrophage marker proteins in human OSCC tissue microarrays, and their correlations with clinicopathological features were analyzed.
    Results  M1 macrophages promoted apoptosis of SCC-15 cells while inhibiting their proliferation, migration, and invasion. In contrast, M2 macrophages exhibited the opposite effects. The infiltration density of tumor-associated macrophages (TAMs) in OSCC tissues was significantly positively correlated (P<0.05) with lymph node metastasis.
    Conclusions  M1 macrophages suppress OSCC progression, whereas M2 macrophages promote it.

     

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