Abstract: Up to 90% of cancer-related deaths worldwide are associated with tumor metastasis. In particular, bone metastases substantially reduces patient survival and quality of life. Abnormal osteoclast activation plays a crucial role in bone metastasis by promoting bone matrix degradation that exacerbates tumor growth and spread. Although osteoclast-targeting drugs, such as bisphosphonates, are widely used in clinical practice, adverse reactions limit their use. Further exploration of the mechanism of action of osteoclasts, as well as non-traditional drug treatments are required to prevent bone metastasis. This article reviews recent domestic and international research into multidisciplinary treatment strategies, including comprehensive chemotherapy, immunotherapy, and targeted therapy. The review aims to stimulate optimization of clinical diagnosis and treatment strategies, development of novel treatment plans, and to provide a new theoretical basis and practical guidance for extending patient survival and improving quality of life.