食管癌综合治疗进展

Advancements in comprehensive treatment strategies for esophageal cancer

  • 摘要: 食管癌是常见的消化道恶性肿瘤,在中国发病率和死亡率较高。多学科综合治疗延长了患者的生存期,但治疗后部分患者仍面临器官功能丧失、生活质量下降及高复发率等问题,疾病负担依然较重。放射治疗在食管癌各阶段治疗中发挥重要作用。随着放疗技术进步、药物研发及新型监测手段的涌现,当前治疗策略和研究方向正逐步向细分患者人群、提供低毒高效的个体化治疗转变。本文就2023年至2024年食管癌放疗领域的最新进展进行综述,重点探讨保器官策略的优化,放疗在新辅助治疗、根治性治疗中的应用,复发/晚期食管癌的挽救性治疗以及放疗相关不良反应管理的研究进展。

     

    Abstract: Esophageal cancer is a common malignant tumor of the digestive system that exhibits high morbidity and mortality rates in China. Multidisciplinary treatment regimens have improved patient survival, but the 5-year survival rate remains low. Challenges including posttreatment organ dysfunction, reduced quality of life, and high recurrence rates continue to impose a significant disease burden. Radiotherapy plays an important role in the treatment of esophageal cancer at all stages. Built upon advances in radiotherapy techniques, development of new drugs, and emergence of novel monitoring methods, current therapeutic strategies and research are increasingly focused on refining patient subgroups to deliver individualized treatments with low-toxicity and high efficacy. In this article, we review advances in radiotherapy for esophageal cancer between 2023 to 2024, focusing on organ preservation strategies, progress in neoadjuvant and definitive therapies, treatment for recurrent or metastatic esophageal cancers, control of side effects during radiotherapy, and methods to predict the efficacy of radiotherapy.

     

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