Abstract: Colorectal cancer (CRC) is a common malignancy of the digestive system, with increasing morbidity and mortality worldwide. The standard treatment for CRC has, in the past, been surgery, chemotherapy, and radiotherapy. However, these treatments have significant side effects and are particularly challenging for patients with advanced metastatic CRC (mCRC). Therefore, it is crucial to explore alternative and more effective treatments. In recent years, with the development of molecular technology, numerous biomarkers have been identified, and targeted therapy and immunotherapy have achieved surprisingly positive results in the treatment of mCRC. Patients receiving targeted therapy and immunotherapy have an improved prognosis and quality of life. On this basis, this article reviews the latest research progress in targeted therapy and immunotherapy for mCRC, providing a reference for precision treatment of mCRC.