Abstract: With the development of breast oncoplasty, a large proportion of Chinese patients with breast cancer have opted for surgical interventions using oncoplastic techniques. For patients requiring radiation therapy, a multidisciplinary decision regarding the inclusion of irradiation in the comprehensive treatment is advocated owing to the adverse impact of irradiation on breast tissue. Guidelines and consensus regarding the application of breast oncoplastic surgery and subsequent radiation are currently lacking. The China Anti-Cancer Association Committee of Oncoplastic Surgery invited experts nationwide to formulate the first consensus on breast oncoplasty and radiation based on evidence-based studies and years of clinical experience. The resulting consensus focuses on breast conservation and post-mastectomy reconstruction, integrating breast imaging, pathology, radiation, and surgery to provide guidance for clinical practice.