胰腺癌纳米刀治疗中国专家共识

Chinese expert consensus on irreversible electroporation treatment for pancreatic cancer

  • 摘要: 胰腺癌是一种恶性程度高、预后差的消化道肿瘤,多数患者确诊时已失去手术机会,局部治疗是改善预后的重要手段之一。纳米刀消融[不可逆电穿孔技术(irreversible electroporation,IRE)]作为一种新型局部消融技术,通过高压电脉冲诱导肿瘤细胞凋亡,同时保护周围血管及管道结构,为胰腺癌治疗提供了新的选择。纳米刀消融技术的规范化应用有望进一步提升胰腺癌的局部控制率,改善患者生存质量。国家恶性肿瘤临床医学研究中心专家组基于循证医学证据制定《胰腺癌纳米刀治疗中国专家共识》,系统阐述了纳米刀消融在胰腺癌治疗中的适应证、禁忌证、操作流程及并发症管理,旨在为临床医生提供实践指导,推动胰腺癌综合治疗的发展。

     

    Abstract: Pancreatic cancer is a highly malignant gastrointestinal tumor with poor prognosis. As most patients are ineligible for surgical resection at diagnosis, local therapy is crucial for improving outcomes. Irreversible electroporation (IRE), a novel local ablation technique, induces tumor cell apoptosis through high-voltage electrical pulses while preserving the adjacent vascular and ductal structures, offering a promising therapeutic option for pancreatic cancer. The standardized application of IRE technology is expected to improve local tumor control rates and enhance the patients' quality of life. The Chinese Expert Consensus on IRE for Pancreatic Cancer, developed by the National Clinical Research Center for Cancer, systematically elaborates the indications, contraindications, procedural protocols, and complication management of IRE in pancreatic cancer treatment. This provides clinical practice guidance for physicians and promotes the advancement of comprehensive pancreatic cancer treatment.

     

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