Abstract:
Pancreatic cancer is a highly malignant gastrointestinal tumor with poor prognosis. As most patients are ineligible for surgical resection at diagnosis, local therapy is crucial for improving outcomes. Irreversible electroporation (IRE), a novel local ablation technique, induces tumor cell apoptosis through high-voltage electrical pulses while preserving the adjacent vascular and ductal structures, offering a promising therapeutic option for pancreatic cancer. The standardized application of IRE technology is expected to improve local tumor control rates and enhance the patients' quality of life. The Chinese Expert Consensus on IRE for Pancreatic Cancer, developed by the National Clinical Research Center for Cancer, systematically elaborates the indications, contraindications, procedural protocols, and complication management of IRE in pancreatic cancer treatment. This provides clinical practice guidance for physicians and promotes the advancement of comprehensive pancreatic cancer treatment.