从影像到病理:人工智能在肾癌精准诊断中的研究进展

Artificial intelligence in radiologic and pathologic diagnosis of renal cell carcinoma:current status and future directions

  • 摘要: 肾细胞癌作为泌尿系统最常见的恶性肿瘤之一,其精准诊断对临床治疗决策和预后改善具有重要意义。近年来,人工智能技术在肾癌影像和病理诊断领域取得了突破性进展。在影像诊断方面,基于深度学习的算法不仅能够实现肿瘤的自动检测和定位,还能通过分析CT、MRI等影像特征,辅助完成良恶性鉴别、病理亚型预测、肿瘤分期及侵袭性评估等复杂任务。在病理诊断领域,人工智能系统通过对全切片数字图像的深度分析,在病理分型、核分级、预后评估等方面展现出接近甚至超越病理专家的性能,同时还能挖掘传统病理学方法难以识别的分子特征和预后相关标志物。然而,当前研究仍面临多中心数据异构性、算法可解释性不足、临床验证不充分等关键挑战。未来研究应着重构建标准化的多中心肾癌数据库,开发融合影像组学、病理组学和基因组学的多模态智能诊断系统,并通过前瞻性临床试验验证其临床应用价值,最终推动肾癌诊疗向精准化、个性化和智能化方向发展。

     

    Abstract: As one of the most common malignant tumors of the urinary system, renal cell carcinoma (RCC) requires a precise diagnosis to guide clinical decision-making and improve prognosis. Recent advances in artificial intelligence (AI) have transformed radiological and pathological approaches to RCC evaluation. In imaging, deep learning algorithms can automatically detect and localize tumors, assisting with complex tasks such as benign-malignant differentiation, histologic subtype prediction, tumor staging, and assessment of invasiveness based on computed tomography (CT) and magnetic resonance imaging (MRI) features. In pathology, AI systems demonstrate performance comparable to or exceeding that of pathologists in tumor classification, nuclear grading, and prognosis prediction by analyzing whole-slide images. These systems can also identify molecular characteristics and prognostic markers that are difficult to detect using conventional methods. However, despite these advances, major challenges remain, including multicenter data heterogeneity, limited algorithm interpretability, and insufficient clinical validation. Future work should focus on the development of standardized, multicenter RCC databases; the creation of multimodal intelligent diagnostic systems that integrate radiomics, pathomics, and genomics; and prospective clinical validation to establish the utility of these approaches. Such efforts will support progress towards more precise, personalized, and intelligent RCC diagnosis.

     

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